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Biomaterials and Biomedical Engineering Volume 1, Number 1, March 2014 , pages 41-50 DOI: https://doi.org/10.12989/bme.2014.1.1.041 |
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The in vivo photothermal treatment of gold nanorod in the mouse ear model |
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Bruce Yao Wen Liu, Cheng-Lung Chen, Shin-Yu Lee, Fu-Hsiung Chang, Win-Li Lin, Chih-Ta Chia and Yang-Yuan Chen
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| Abstract | ||
| Gold nanorod’s exceptional light to heat transduction is a robust phonomenon that has been extensively verified. The phenomenon is a trait from which many novel applications across disciplines have been proposed. In this investigation, the feasibility of utilizing heat harvested from such photothermal method to combat cancer is presented. Using non-invasive laser methods, an in vivo study is conducted on mouse ear tumors administered with gold nanorods (Au NRs). An emphasis is placed on monitoring the tumor developments after photothermal treatments, over time. The findings reveal significant tumor growth surpression at a threshold laser power of 0.6 W⁄cm2 lasting 2 minutes; this energy also brought about dramatic size reduction in treated tumors. Furthermore, the apparent formation of an eschar over the laser treated region indicates extensive hemorrhagic necrosis of the tumor tissue; a phenomenon implicative to the inhibition of angiogenesis. | ||
| Key Words | ||
| gold nanorod; photothermal; tumor; laser; cancer; necrosis | ||
| Address | ||
| Bruce Yao Wen Liu, Cheng-Lung Chen, Shin-Yu Lee and Yang-Yuan Chen: Institute of Physics, Academia Sinica, Taipei, Taiwan Bruce Yao Wen Liu and Chih-Ta Chia: Department of Physics, National Taiwan Normal University, Taipei, Taiwan Fu-Hsiung Chang: Institute of Biochemistry and Molecular Biology, National Taiwan University, Taipei, Taiwan Win-Li Lin: Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan Yang-Yuan Chen: Graduate Institute of Applied Physics, National Chengchi University, Taipei, Taiwan | ||
