Techno Press
You logged in as Techno Press

Smart Structures and Systems
  Volume 8, Number 1, July 2011 , pages 17-37

Microcantilever biosensor: sensing platform, surface characterization and multiscale modeling
Chuin-Shan Chen, Shu Kuan, Tzu-Hsuan Chang, Chia-Ching Chou, Shu-Wei Chang and Long-Sun Huang

    The microcantilever (MCL) sensor is one of the most promising platforms for next-generation label-free biosensing applications. It outperforms conventional label-free detection methods in terms of portability and parallelization. In this paper, an overview of recent advances in our understanding of the coupling between biomolecular interactions and MCL responses is given. A dual compact optical MCL sensing platform was built to enable biosensing experiments both in gas-phase environments and in solutions. The thermal bimorph effect was found to be an effective nanomanipulator for the MCL platform calibration. The study of the alkanethiol self-assembly monolayer (SAM) chain length effect revealed that 1-octanethiol (C8H17SH) induced a larger deflection than that from 1-dodecanethiol (C12H25SH) in solutions. Using the clinically relevant biomarker Creactive protein (CRP), we revealed that the analytical sensitivity of the MCL reached a diagnostic level of 1~500
Key Words
    microcantilever (MCL); label-free; biomolecular interaction; biosensing; self-assembly; antigen; microfluidics; x-ray photoelectron spectroscopy (XPS); multiscale modeling.
Chuin-Shan Chen, Tzu-Hsuan Chang, Chia-Ching Chou and
Shu-Wei Chang: Department of Civil Engineering, National Taiwan University, Taipei 10617, Taiwan
Shu Kuan and Long-Sun Huang: Institute of Applied Mechanics, National Taiwan University, Taipei 10617, Taiwan

Techno-Press: Publishers of international journals and conference proceedings.       Copyright © 2023 Techno Press
P.O. Box 33, Yuseong, Daejeon 305-600 Korea, Tel: +82-42-828-7996, Fax : +82-42-828-7997, Email: