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Biomaterials and Biomedical Engineering
  Volume 2, Number 2, June 2015, pages 85-96
DOI: https://doi.org/10.12989/bme.2015.2.2.085
 
open access

In-vitro elution of cisplatin and fluorouracil from bi-layered biodegradable beads
Kuo-Sheng Liu, Ko-Ang Pan and Shih-Jung Liu

 
Abstract
    This study developed biodegradable bi-layered drug-eluting beads and investigated the in-vitro release of fluorouracil and cisplatin from the beads. To manufacture the drug-eluting beads, poly[(d,l)-lactide-co-glycolide] (PLGA) with lactide:glycolide ratios of 50:50 and 75:25 were mixed with fluorouracil or cisplatin. The mixture was compressed and sintered at 55
 
Key Words
    biodegradable bi-layered beads; polylactide-polyglycolide (PLGA); in vitro release; fluorouracil; cisplatin
 
Address
Kuo-Sheng Liu: Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Linkou,
College of Medicine, Chang Gung University, Tao-Yuan, Taiwan

Kuo-Sheng Liu, Ko-Ang Pan and Shih-Jung Liu: Department of Mechanical Engineering, Chang Gung University, Tao-Yuan, Taiwan
 

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