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Biomaterials and Biomedical Engineering Volume 2, Number 2, June 2015 , pages 71-84 DOI: https://doi.org/10.12989/bme.2015.2.2.071 |
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A novel low-profile flow sensor for monitoring of hemodynamics in cerebral aneurysm |
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Yanfei Chen, Brian T. Jankowitz, Sung Kwon Cho, Woon-Hong Yeo and Youngjae Chun
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| Abstract | ||
| A low-profile flow sensor has been designed, fabricated, and characterized to demonstrate the feasibility for monitoring hemodynamics in cerebral aneurysm. The prototype device is composed of three micro-membranes (500-µm-thick polyurethane film with 6-µm-thick layers of nitinol above and below). A novel super-hydrophilic surface treatment offers excellent hemocompatibility for the thin nitinol electrode. A computational study of the deformable mechanics optimizes the design of the flow sensor and the analysis of computational fluid dynamics estimates the flow and pressure profiles within the simulated aneurysm sac. Experimental studies demonstrate the feasibility of the device to monitor intra-aneurysmal hemodynamics in a blood vessel. The mechanical compression test shows the linear relationship between the applied force and the measured capacitance change. Analytical calculation of the resonant frequency shift due to the compression force agrees well with the experimental results. The results have the potential to address important unmet needs in wireless monitoring of intra-aneurysm hemodynamic quiescence. | ||
| Key Words | ||
| cerebral aneurysm; flow sensor; thin film nitinol; capacitance; finite element modeling | ||
| Address | ||
| Yanfei Chen, Youngjae Chun: Department of Industrial Engineering, University of Pittsburgh, Pittsburgh, PA 15261, USA Brian T. Jankowitz: Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA Sung Kwon Cho: Department of Mechanical Engineering and Materials Science, University of Pittsburgh, Pittsburgh, PA 15261, USA Woon-Hong Yeo: Department of Mechanical and Nuclear Engineering, Center for Rehabilitation Science and Engineering, Virginia Commonwealth University, Richmond, VA 23284, USA. Youngjae Chun: Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA | ||
