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Biomaterials and Biomedical Engineering
  Volume 2, Number 1, March 2015, pages 1-13
DOI: https://doi.org/10.12989/bme.2015.2.1.001
 
open access

Recent advances in utilization of photochemical internalization (PCI) for efficient nano carrier mediated drug delivery
Wooram Park, Sin-jung Park, Jun Lee and Kun Na

 
Abstract
    Despite recent progresses in nanoparticle-based drug delivery systems, there are still many unsolved limitations. Most of all, a major obstacle in current nanoparticle-based drug carrier is the lack of sufficient drug delivery into target cells due to various biological barriers, such as: extracellular matrix, endolysosomal barrier, and drug-resistance associated proteins. To circumvent these limitations, several research groups have utilized photochemical internalization (PCI), an extension of photodynamic therapy (PDT), in design of innovative and efficient nano-carriers drug delivery. This review presents an overview of a recent research on utilization of PCI in various fields including: anti-cancer therapy, protein delivery, and tissue engineering.
 
Key Words
    photochemical internalization (PCI); photosensitizer; drug delivery system (DDS); nanoparticles; biological barriers
 
Address
Wooram Park, Sin-jung Park, Kun Na: Center for Photomedicine, Department of Biotechnology, The Catholic University of Korea, 43 Jibong-ro, Wonmi-gu, Bucheon-si, Gyeonggi do, 420-743, Korea

Jun Lee: Gyeonggi-Academy of Foreign Languages, 30, 105 105 Gosan-ro, Uiwang-si, Gyeonggi-do, 437-010, Korea
 

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