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Biomaterials and Biomedical Engineering
  Volume 1, Number 3, September 2014, pages 151-162
DOI: http://dx.doi.org/10.12989/bme.2014.1.3.151
 
open access

Delivery of growth factor-associated genes to mesenchymal stem cells for cartilage and bone tissue regeneration
Jongchan Ahn, Seah Park, Byung-Hyun Cha, Jae Hwan Kim, Hansoo Park, Yoon Ki Joung, Inbo Han and Soo-Hong Lee

 
Abstract
    Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone regeneration, while MSCs with TGF-b gene did cartilage regeneration. In this review, we introduce several growth factors for gene delivery to MSCs and strategies for bone and cartilage tissue regeneration using GM-MSCs. Furthermore, we describe strategies for strengthening GM-MSCs to more intensively induce tissue regeneration by co-delivery system of multiple genes.
 
Key Words
    growth factor; transcription factor; genetically-modified mesenchymal stem cells; cartilage; bone; tissue regeneration
 
Address
Jongchan Ahn, Seah Park, Byung-Hyun Cha, Jae Hwan Kim, Yoon Ki Joung, Soo-Hong Lee: Department of Biomedical Science, CHA University, Bundang-gu, Gyeonggi-do, Republic of Korea

Hansoo Park, Yoon Ki Joung: Department of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea

Inbo Han: Department of Neurosurgery, Bundang Medical Center, CHA University, Bundang-gu, Gyeonggi-do, Republic of Korea
 

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