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Biomaterials and Biomedical Engineering Volume 1, Number 3, September 2014 , pages 151-162 DOI: https://doi.org/10.12989/bme.2014.1.3.151 |
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Delivery of growth factor-associated genes to mesenchymal stem cells for cartilage and bone tissue regeneration |
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Jongchan Ahn, Seah Park, Byung-Hyun Cha, Jae Hwan Kim, Hansoo Park, Yoon Ki Joung, Inbo Han and Soo-Hong Lee
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| Abstract | ||
| Genetically-modified mesenchymal stem cells (GM-MSCs) have emerged as promising therapeutic tools for orthopedic degenerative diseases. GM-MSCs have been widely reported that they are able to increase bone and cartilage tissue regeneration not only by secreting transgene products such as growth factors in a long-term manner, also by inducing MSCs into tissue-specific cells. For example, MSCs modified with BMP-2 gene increased secretion of BMP-2 protein resulting in enhancement of bone regeneration, while MSCs with TGF-b gene did cartilage regeneration. In this review, we introduce several growth factors for gene delivery to MSCs and strategies for bone and cartilage tissue regeneration using GM-MSCs. Furthermore, we describe strategies for strengthening GM-MSCs to more intensively induce tissue regeneration by co-delivery system of multiple genes. | ||
| Key Words | ||
| growth factor; transcription factor; genetically-modified mesenchymal stem cells; cartilage; bone; tissue regeneration | ||
| Address | ||
| Jongchan Ahn, Seah Park, Byung-Hyun Cha, Jae Hwan Kim, Yoon Ki Joung, Soo-Hong Lee: Department of Biomedical Science, CHA University, Bundang-gu, Gyeonggi-do, Republic of Korea Hansoo Park, Yoon Ki Joung: Department of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea Inbo Han: Department of Neurosurgery, Bundang Medical Center, CHA University, Bundang-gu, Gyeonggi-do, Republic of Korea | ||
