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Biomaterials and Biomedical Engineering
  Volume 1, Number 3, September 2014, pages 131-150
DOI: http://dx.doi.org/10.12989/bme.2014.1.3.131
 
open access

Coating defects in polymer-coated drug-eluting stents
Tarek M. Bedair, Youngjin Cho, Bang Ju Park,Yoon Ki Joung and Dong Keun Han

 
Abstract
    Vascular stenting has a great attention as a treatment for coronary arteries diseases as compared with percutaneous balloon angioplasty. In-stent restenosis and thrombosis are side effects resulting from using bare metal stent (BMS). Employing platelet therapy allowed to reduce the rate of thrombosis, however, the rate of restenosis remains a major problem. In 2002, drug-eluting stents (DESs) were introduced as an effort to reduce the restenosis. The commercially available DESs continue to suffer from coating defects that might lead to a series of adverse effects. Most importantly, multiple concerns remain regarding the polymer coating integrity on metal surfaces or the relation of polymer irregularities to long-term adverse events.
 
Key Words
    drug-eluting stent; thrombosis; restenosis; coating defects; durability
 
Address
Tarek M. Bedair, Youngjin Cho, Yoon Ki Joung and Dong Keun Han: Center for Biomaterials, Biomedical Research Institute, Korea

Institute of Science and Technology, Hwarangno 14-gil 5, Seongbuk-gu, Seoul 136-791, Republic of Korea

Tarek M. Bedair, Yoon Ki Joung and Dong Keun Han: Department of Biomedical Engineering, Korea University of Science and Technology,113 Gwahangno,Yuseong-gu, Daejeon 305-333, Republic of Korea

Tarek M. Bedair: Chemistry Department, Faculty of Science, Minia University, El-Minia 61519, Egypt

Bang Ju Park: Department of Electronic Engineering & Institute of Gachon Fusion Technology, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si, Gyeonggi 146-701, Republic of Korea
 

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