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Biomaterials and Biomedical Engineering
  Volume 1, Number 2, June 2014 , pages 105-116
 open access

Preparation and characterization of a thermal responsive of poly(N-isopropylacrylamide)/chitosan/gelatin hydrogels
Shaghayegh Baghaei and Mohammad T. Khorasani

    Synthesis of interpenetrating polymer network (IPN) of chitosan-gelatin (Cs-Ge) (as a primary network) and N-isopropylacrylamide (NIPAAm) monomer (as the secondary network) was carried out with different ratio. Its structure was characterized by FT-IR, which indicated that the IPN was formed. The memberanes were studied by swelling, weight loss with time. The interior morphology of the IPN hydrogels was revealed by scanning electron microscopy (SEM); the IPN hydrogels showed a interpenetrated network of NIPAAm/chitosan has layers with more minute stoma and canals compared to interpenetrated network of NIPAAm/gelatin. Lower critical solution temperature (LCST), equilibrium swelling ratio (ESR) and de-swelling kinetics were measured. The DSC results noticed that LCST of IPN hydrogels with different ratio of Cs/Ge/PNIPAAm are around 33
Key Words
    gelatin; chitosan; N-isopropylacrylamide; thermosensitive hydrogel
Shaghayegh Baghaei: Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Mohammad T. Khorasani: Biomaterial Department of Iran Polymer and Petrochemical Institute, P.O. BOX 14965/115, Tehran, Iran

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