|
Biomaterials and Biomedical Engineering Volume 1, Number 2, June 2014 , pages 73-79 DOI: https://doi.org/10.12989/bme.2014.1.2.073 |
||
 open accessPolyvinyl butyral DMN-conjugates for the controlled release of singlet oxygen in medical and antimicrobial applications |
||
Damir Posavec, Rainer Muller, Udo Bogner, Gunther Bernhardt and Gunther Knor
|
||
| Abstract | ||
| Covalent attachment of 1, 4-dimethylnaphthalene (DMN) based endoperoxide forming subunits to a polyvinyl butyral (PVB) backbone has been achieved. The functionalized polymer materials prepared and characterized here can serve as biocompatible carrier systems for studying cellular uptake, intermediate storage and delayed release of singlet oxygen, which opens up new doors for optimizing a variety of medical applications of photogenerated DMN-endoperoxides such as antiviral, antibacterial, antiplasmodial and antitumor activity. | ||
| Key Words | ||
| dimethyl naphthalene; Polyvinyl butyral; endoperoxides; singlet oxygen; drug carriers | ||
| Address | ||
| Damir Posavec and Gunther Knor: Institute of Inorganic Chemistry, Johannes Kepler University Linz (JKU), Altenbergerstrasse 69, A-4040 Linz, Austria Rainer Muller and Udo Bogner: Institute of Physical and Theoretical Chemistry, University of Regensburg, 93040 Regensburg, Germany Gunther Bernhardt: Institute of Pharmacy, University of Regensburg, 93040 Regensburg, Germany | ||
