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Biomaterials and Biomedical Engineering Volume 1, Number 2, June 2014 , pages 63-71 DOI: https://doi.org/10.12989/bme.2014.1.2.063 |
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 open accessSynthesis and characterization of silk fibroin-bioactive glass hybrid xerogels |
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Xiaohong Wu, Fuhua Yan, Wei Liu, Hongbing Zhan and Wenrong Yang
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| Abstract | ||
| This study aimed to develop a novel bioactive hybrid xerogel consisting of silk fibroin /SiO2-CaO-P2O5 by sol-gel process at room temperature. Scanning electron microscopy (SEM), FT-IR Spectroscopy, pore measurement, mechanical property testing, in vitro bioactivity test and cytotoxicity assay were performed to characterize the xerogel for bone tissue engineering application. We have found that the xerogel possessed excellent pore structures and mechanical property. Once immersed in a simulated fluid (SBF), the xerogel exhibited profound bioactivity by inducing hydroxyapatite layers on its surfaces. The cell toxicity study also demonstrated that there was little toxic to MC3T3-E1 cells. These results indicate that silk fibroin /SiO2-CaO-P2O5 hybrid xerogel potentially could be used as a bone tissue engineering material. | ||
| Key Words | ||
| hybrid; xerogel; silk fibroin; SiO2-CaO-P2O5; bone tissue engineering | ||
| Address | ||
| Xiaohong Wu: School and Hospital of Stomatology, Fujian Medical University, 246 Yangqiao Zhong Road,Fuzhou 350002, China Fuhua Yan: Institute and Hospital of Stomatology, Nanjing University Medical School, 30 Zhongyang Road, Nanjing, Jiangsu, 210008, China. Wei Liu and Hongbing Zhan: College of Materials Science and Engineering, Fuzhou University, 2 Xueyuan Road, Fuzhou 350108, China Wenrong Yang: School of Life and Environmental Science, Waurn Ponds Campus, Geelong Deakin University, Australia | ||
