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Advances in Nano Research
  Volume 6, Number 2, June 2018, pages 183-200

Synthesis, characterization and dose dependent antimicrobial and anticancerous efficacy of phycogenic (Sargassum muticum) silver nanoparticles against Breast Cancer Cells (MCF 7) cell line
Nookala Supraja, J. Dhivya, T.N.V.K.V. Prasad and Ernest David

Abstract     [Full Text]
    In the present study silver nanoparticles (AgNPs) were successfully synthesized using aqueous extract of Sargassum muticum. The aqueous extract (10%) treated with 1 mM silver nitrate solution resulted in the formation of AgNPs and the surface plasmon resonance (SPR) of the formed AgNPs was recorded at 360 nm using UV-Visible spectrophotometer. The molecules involved in the formation of AgNPs were identified by Fourier transform infrared spectroscopy (FT-IR), surface morphology was studied by using scanning electron microscopy (SEM), SEM micrograph clearly revealed the size of the AgNPs was in the range of 40-65 nm with spherical, hexagonal in shape and poly-dispersed nature, and X-ray diffraction spectroscopy (XRD) was used to determine the crystalline structure. High positive Zeta potential (36.5 mV) of formed AgNPs indicates the stability and XRD pattern revealed the crystal structure of the AgNPs by showing the Bragg's peaks corresponding to (111), (200), (311) and (222) planes of facecentered cubic crystal phase of silver. The synthesized AgNPs exhibited effective anticancerous activity (at doses 25 and 50 μg/ml of AgNPs) against Breast cancer cell line (MCF7).
Key Words
    Sargassum muticum; silver nanoparticles; antimicrobial activity; anti-cancerous efficacy
(1) Nookala Supraja, J. Dhivya, Ernest David:
Department of Biotechnology, Thiruvalluvar University, Serkkadu, Vellore 632 115, TN, India;
(2) T.N.V.K.V. Prasad:
Nanotechnology Laboratory, Institute of Frontier Technology, Regional Agricultural Research Station, Acharya N G Ranga Agricultural University, Tirupathi 517 502, AP, India.

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