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Advances in Nano Research Volume 6, Number 1, March 2018 , pages 1-19 DOI: https://doi.org/10.12989/anr.2018.6.1.001 |
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A review: Synthetic strategy control of magnetite nanoparticles production |
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Ahmad H.M. Yusoff, Midhat N. Salimi and Mohd F. Jamlos
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| Abstract | ||
| Iron oxide nanoparticles excite researcher interest in biomedical applications due to their low cost, biocompatibility and superparamagnetism properties. Magnetic iron oxide especially magnetite (Fe3O4) possessed a superparamagnetic behaviour at certain nanosize which beneficial for drug and gene delivery, diagnosis and imaging. The properties of nanoparticles mainly depend on their synthesis procedure. There has been a massive effort in developing the best synthetic strategies to yield appropriate physico-chemical properties namely co-precipitation, thermal decomposition, microemulsions, hydrothermal and sol-gel. In this review, it is discovered that magnetite nanoparticles are best yielded by co-precipitation method owing to their simplicity and large production. However, its magnetic saturation is within range of 70-80 emu/g which is lower than thermal decomposition and hydrothermal methods (80-90 emu/g) at 100 nm. Dimension wise, less than 100 nm is produced by co-precipitation method at 70°C-80°C while thermal decomposition and hydrothermal methods could produce less than 50 nm but at very high temperature ranging between 200°C and 300°C. Thus, co-precipitation is the optimum method for pre-compliance magnetite nanoparticles preparation (e.g., 100 nm is fit enough for biomedical applications) since thermal decomposition and hydrothermal required more sophisticated facilities. | ||
| Key Words | ||
| nano-medicine; chemical synthesis; nano-particles; nanobiotechnology | ||
| Address | ||
| (1) Ahmad H.M. Yusoff, Midhat N. Salimi: School of Bioprocess Engineeering, Universiti Malaysia Perlis, 02600, Arau, Malaysia; (2) Mohd F. Jamlos: School of Computer and Communication Engineering, University Malaysia Perlis, 02600 Arau, Malaysia. | ||