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Advances in Materials Research Volume 3, Number 4, December 2014 , pages 183-197 DOI: https://doi.org/10.12989/amr.2014.3.4.183 |
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Radiation induced synthesis of (gelatin-co-PVA)-g-poly (AAc) copolymer as wound dressing material |
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Inderjeet Kaur, Pooja Bhati and Sushma Sharma
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| Abstract | ||
| Copolymers of gelatin and poly (vinyl alcohol), (PVA) grafted by acrylic acid (AAc) with excellent water absorption and retention abilities under neutral conditions were successfully synthesized using 60Co gamma radiations in presence of ammonium persulphate (APS), as water soluble initiator and sodium bicarbonate (NaHCO3) as foaming agent. The optimum synthesis conditions pertaining to maximum swelling percentage were evaluated as a function of gelatin/PVA ratio, amount of water, concentration of APS, NaHCO3, monomer concentration and total irradiation dose. Maximum percent swelling (1694.59%) of the copolymer, gelatin-co-PVA, was obtained at optimum [APS] = 2.92x10-1 mol/L, [NaHCO3] = 7.94x10-2 mol/L and 1.5 mL of water at total dose of 31.104 kGy while in case of grafted copolymer, (gelatin-co-PVA)-g-poly(AAc), maximum percent swelling (560.86%) was obtained using 8.014x10-1 mol/ L of AAc in 9 mL water with 31.104 kGy preirradiation dose. The pristine and grafted copolymers were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron Microscopy (SEM), Thermal gravimetric analysis (TGA) and X-Ray Diffraction (XRD) methods. The copolymers loaded with an antiseptic, Povidone, were used as wound dressing materials for wounded gastrocnemius muscle of mice and the results exhibit that (gelatin-co-PVA)-g-poly (AAc) copolymer is a potent wound dressing material as compared to the copolymer. | ||
| Key Words | ||
| PVA; gelatin; acrylic acid; gamma ray irradiation; APS, sodium bicarbonate | ||
| Address | ||
| Inderjeet Kaur and Pooja Bhati: Department of Chemistry, Himachal Pradesh University Summer Hill, Shimla, India, 171 005 Sushma Sharma: Department of Bio sciences, Himachal Pradesh University Summer Hill, Shimla, India, 171005 | ||
