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Advances in Environmental Research
  Volume 7, Number 3, September 2018, pages 201-212
DOI: http://dx.doi.org/10.12989/aer.2019.7.3.201
 
open access

Determination of antibiotics by SPE-LC-MS/MS in wastewater and risk assessment
Senar Aydin, Mehmet E. Aydin, Arzu Ulvi and Havva Kilic

 
Abstract
    In this study, conditions of solid phase extraction (SPE) for determination of some antibiotics such as trimethoprim, oxytetracycline, erythromycin, clarithromycin, azythromycin, doxycycline, sulfamethazine, ciprofloxacin, chlortetracycline, sulfamethoxazole in wastewaters were optimized. After the optimum volume and pH of the sample were determined, the effect of the concentration of the compounds and matrix were investigated. The highest recovery rates for antibiotic compounds were determined between 82% and 105% in 200 mL sample volume and pH 2.5. Then, antibiotic compounds were investigated in influent and effluent samples taken from Konya Urban Wastewater Treatment Plant. The concentration of the antibiotics was detected range of 0.11-101 ng/L in influent waters and less than dl-288 ng/L in effluent samples in wastewater treatment plant. Hazard quotients (HQs) of antibiotic compounds determined in WWTP effluents to evaluate the risk towards different aquatic organisms (algae, Daphnia magna and fish) were determined. Azythromycin for fish and erythromycin, sulfamethoxazole, ciprofloxacin, clarithromycin for algae posed a moderate risk while azythromycin, ciprofloxacin, clarithromycin, oxytetracycline posed a high risk for algae in the receiving environment.
 
Key Words
    antibiotic; LC-MS/MS; risk assessment; SPE, wastewater
 
Address
Senar Aydin, Arzu Ulvi and Havva Kilic: Department of Environmental Engineering, Faculty of Engineering and Architecture, Necmettin Erbakan University, 42140 Konya-Turkey

Mehmet E. Aydin: Department of Civil Engineering, Faculty of Engineering and Architecture, Necmettin Erbakan University, 42140 Konya-Turkey
 

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